Journal
IMMUNOBIOLOGY
Volume 219, Issue 4, Pages 315-322Publisher
ELSEVIER GMBH
DOI: 10.1016/j.imbio.2013.11.003
Keywords
Cytokine; DMSO; Inflammasome; Interleukin-1; Macrophages; NLRP3
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Funding
- Ministry of Education, Science and Technology [NRF-2012R1A1A1001645]
- Kangwon National University
- Basic Science Research Program through the National Research Foundation of Korea (NRF)
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Dimethyl sulfoxide (DMSO) is an amphipathic molecule that is commonly/widely used as a solvent for biological compounds. In addition, DMSO has been studied as a medication for the treatment of inflammation, cystitis, and arthritis. Based on the anti-inflammatory characteristics of DMSO, we elucidated the effects of DMSO on activation of inflammasomes, which are cytoplasmic multi-protein complexes that mediate the maturation of interleukin (IL)-1 beta by activating caspase-1 (Caspl). In the present study, we prove that DMSO attenuated IL-1 beta maturation, Caspl activity, and ASC pyroptosome formation via NLRP3 inflammasome activators. Further, NLRC4 and AIM2 inflammasome activity were not affected, suggesting that DMSO is a selective inhibitor of the NLRP3 inflammasomes. The anti-inflammatory effect of DMSO was further confirmed in animal, LPS-endotoxin sepsis and inflammatory bowel disease models. In addition, DMSO inhibited LPS-mediating IL-1s transcription. Taken together, DMSO shows anti-inflammatory characteristics, attenuates NLRP3 inflammasome activation, and mediates inhibition of IL-1s transcription. Crown Copyright (C) 2013 Published by Elsevier GmbH. All rights reserved.
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