Journal
IMMUNOBIOLOGY
Volume 216, Issue 10, Pages 1127-1134Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.imbio.2011.04.004
Keywords
Mycobacteria; Anaemia; Lipocalin-2; NRAMP1; Hepcidin
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Funding
- EEC [LSHM-CT-2006037296 Eurolron1]
- FCT [POCTI/MGI/40132/2001, SFRH/BD/29257/2006]
- FEDER
- Fundação para a Ciência e a Tecnologia [SFRH/BD/29257/2006, POCTI/MGI/40132/2001] Funding Source: FCT
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Anaemia is a frequent complication of chronic infectious diseases but the exact mechanisms by which it develops remain to be clarified. In the present work, we used a mouse model of mycobacterial infection to study molecular alterations of iron metabolism induced by infection. We show that four weeks after infection with Mycobacterium avium BALB/c mice exhibited a moderate anaemia, which was not accompanied by an increase on hepatic hepcidin mRNA expression. Instead, infected mice presented increased mRNA expression of ferroportin (SIc40a1), ceruloplasmin (Cp), hemopexin (Hpx), heme-oxygenase-1 (Hmox1) and lipocalin-2 (Lcn2). Both the anaemia and the mRNA expression changes of iron-related genes were largely absent in C.D2 mice which bear a functional allele of the Nramp1 gene. Data presented in this work suggest that anaemia due to a chronic mycobacterial infection may develop in the absence of elevated hepcidin expression, is influenced by Nramp1 and may involve lipocalin-2. (c) 2011 Elsevier GmbH. All rights reserved.
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