Journal
IMMUNOBIOLOGY
Volume 215, Issue 9-10, Pages 674-684Publisher
ELSEVIER GMBH
DOI: 10.1016/j.imbio.2010.05.027
Keywords
Inflammation; Macrophage; Neurotransmitter; Neurotrophins; Wound healing
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Funding
- Deutsche Forschungsgemeinschaft [GRK 757, SFB 815, FOG 784]
- Sander Foundation
- LOEWE (LiFF)
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Macrophages are key players not only during initiation of inflammation but also during its resolution. This is achieved by their high functional plasticity and the demand to recognize an enormous repertoire of danger signals and cytokines/chemokines derived from adaptive immune cells. Studies predominantly conducted over the last two decades implicate that macrophage responses are also modulated by neuronal mediators such as neurotransmitters or neurotrophic factors. Here we summarize the current understanding of neuromediator-dependent interplay between macrophages and the nervous system. (C) 2010 Elsevier GmbH. All rights reserved.
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