Journal
IMMUNOBIOLOGY
Volume 213, Issue 9-10, Pages 701-713Publisher
ELSEVIER GMBH
DOI: 10.1016/j.imbio.2008.07.008
Keywords
Bacterial infection; Innate immunity; TREM-1; TREM-2
Categories
Ask authors/readers for more resources
Triggering receptor expressed on myeloid cells (TREM) proteins play important roles in innate and adaptive immunity. Since the discovery of TREM-1 and TREM-2 in 2000, the field has exploded over the past 8 years and currently TREM-1 is thought of as an amplifier of the immune response, while TREM-2 is believed to be a negative regulator. Here, we discuss the current state of the literature on TREMs, with a focus on TREM-1 and TREM-2 and their expression, signaling in mononuclear phagocytes and roles in innate immunity and bacterial infection. (C) 2008 Elsevier GmbH. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available