Journal
IMMUNOBIOLOGY
Volume 212, Issue 9-10, Pages 771-784Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.imbio.2007.09.018
Keywords
macrophage; IFN-gamma; p47 IRG; GBP; GTPase; phagosome; autophagy
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Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI068041] Funding Source: NIH RePORTER
- NIAID NIH HHS [R01 AI068041-01A1, R01 AI068041-02, R01 AI068041-03, R01 AI068041] Funding Source: Medline
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Vertebrates have evolved complex immune specificity repertoires beyond the primordial components found in lower multi-cellular organisms to combat microbial infections. The type 11 interferon (IFN-gamma) pathway represents one such system, bridging innate and acquired immunity and providing host protection in a cell-autonomous manner. Recent large-scale transcriptome analyses of IFN-gamma-dependent gene expression in effector cells such as macrophages have highlighted the prominence of two families of GTPases-p47 IRGs and p65 GBPs-that are now beginning to emerge as major determinants of antimicrobial resistance. Here we discuss the recent clarification of known family members, their cellular biochemistry and host defense functions as a means to understanding the complex innate immune response engendered in higher vertebrates such as humans and mice. (c) 2007 Elsevier GrnbH. All rights reserved.
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