Journal
IMMUNITY
Volume 41, Issue 4, Pages 529-542Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2014.10.004
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Funding
- NIAID NIH HHS [UM1 AI100663, U19 AI109976, R01 AI063107, R01 AI072543, U19 AI090970] Funding Source: Medline
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Follicular helper T (Tfh) cells are specialized providers of T cell help to B cells, and are essential for germinal center formation, affinity maturation, and the development of most high-affinity antibodies and memory B cells. Tfh cell differentiation is a multistage, multifactorial process involving B cell lymphoma 6 (Bcl6) and other transcription factors. This article reviews understanding of Tfh cell biology, including their differentiation, migration, transcriptional regulation, and B cell help functions. Tfh cells are critical components of many protective immune responses against pathogens. As such, there is strong interest in harnessing Tfh cells to improve vaccination strategies. Tfh cells also have roles in a range of other diseases, particularly autoimmune diseases. Overall, there have been dramatic advances in this young field, but there is much to be learned about Tfh cell biology in the interest of applying that knowledge to biomedical needs.
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