Journal
IMMUNITY
Volume 38, Issue 6, Pages 1250-1260Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2013.05.009
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Funding
- National Institutes of Health [R01AI75168, R37AI38903]
- Cancer Biology Postdoctoral Training [5T32CA009138-38]
- Leukemia and Lymphoma Career Development Award
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The CD8(+) memory T cell population is heterogeneous, and it is unclear which subset(s) optimally mediate the central goal of the immune system-protection against infection. Here we investigate the protective capacities of CD8(+) T cell subsets present at the memory stage of the immune response. We show that a population of CD8(+) T cells bearing markers associated with effector cells (KLRG1(hi), CD27 lo, T-bet hi, Eomes lo) persisted to the memory phase and provided optimal control of Listeria monocytogenes and vaccinia virus, despite weak recall proliferative responses. After antigen-specific boosting, this population formed the predominant secondary memory subset and maintained superior pathogen control. The effector-like memory subset displayed a distinct pattern of tissue distribution and localization within the spleen, and their enhanced capacity to eliminate Listeria involved specialized utilization of cytolysis. Together, these data suggest that long-lived effector CD8(+) T cells are optimal for protective immunity against certain pathogens.
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