Journal
IMMUNITY
Volume 39, Issue 2, Pages 286-297Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2013.07.013
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Funding
- Starr Cancer Consortium [13-A123]
- Rita Allen Foundation
- NBRPC [2012CB316503]
- NIH [HG001696]
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Memory T cells protect hosts from pathogen reinfection, but how these cells emerge from a pool of antigen-experienced T cells is unclear. Here, we show that mice lacking the transcription factor Foxo1 in activated CD8(+) T cells have defective secondary, but not primary, responses to Listeria monocytogenes infection. Compared to short-lived effector T cells, memory-precursor T cells expressed higher amounts of Foxo1, which promoted their generation and maintenance. Chromatin immunoprecipitation sequencing revealed the transcription factor Tcf7 and the chemokine receptor Ccr7 as Foxo1-bound target genes, which have critical functions in central-memory T cell differentiation and trafficking. These findings demonstrate that Foxo1 is selectively incorporated into the genetic program that regulates memory CD8(+) T cell responses to infection.
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