Journal
IMMUNITY
Volume 38, Issue 4, Pages 831-844Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2012.12.008
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Funding
- Baylor Health Care System Foundation
- National Institutes of Health [U19 AI08998, U19 AI057234, U01 AI082110, N01-AI-15416, P01 CA084512]
- Erwin Schrodinger Research Grant of the Austrian Science Fund
- Medical Research Fund MFF Tirol
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Systems immunology approaches were employed to investigate innate and adaptive immune responses to influenza and pneumococcal vaccines. These two non-live vaccines show different magnitudes of transcriptional responses at different time points after vaccination. Software solutions were developed to explore correlates of vaccine efficacy measured as antibody titers at day 28. These enabled a further dissection of transcriptional responses. Thus, the innate response, measured within hours in the peripheral blood, was dominated by an interferon transcriptional signature after influenza vaccination and by an inflammation signature after pneumococcal vaccination. Day 7 plasmablast responses induced by both vaccines was more pronounced after pneumococcal vaccination. Together, these results suggest that comparing global immune responses elicited by different vaccines will be critical to our understanding of the immune mechanisms underpinning successful vaccination.
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