Journal
IMMUNITY
Volume 38, Issue 1, Pages 166-175Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2012.09.022
Keywords
-
Categories
Funding
- Howard Hughes Medical Institute, NIH [AI026918, AI30663, AI078869]
- SABRE Center at UCSF
- NIH [HD044331, AI095319]
- AAAAI-GSK Career Development Award
- A.P. Giannini Medical Research Foundation
- German Research Council (DFG) [CRC/SFB832]
- German-Israeli Foundation for Scientific Research and Development [993/2008]
Ask authors/readers for more resources
Mast cells are tissue-resident immune cells that play a central role in allergic disease. These contributions are largely dependent on the acquisition of antigen-specific immunoglobulin E (IgE). Despite this requirement, studies of mast cell and IgE interactions have overlooked the mechanism by which mast cells acquire IgE from the blood. To address this gap, we developed reporter IgE molecules and employed imaging techniques to study mast cell function in situ. Our data demonstrate that skin mast cells exhibit selective uptake of IgE based on perivascular positioning. Furthermore, perivascular mast cells acquire IgE by extending cell processes across the vessel wall to capture lumina! IgE. These data demonstrate how tissue mast cells acquire IgE and reveal a strategy by which extravascular cells monitor blood contents to capture molecules central to cellular function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available