Journal
IMMUNITY
Volume 36, Issue 2, Pages 288-297Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2012.02.006
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Funding
- Landsteiner Foundation for Blood Transfusion Research (LSBR) [0210]
- Netherlands Organization for Scientific Research (NWO) [016.048.603, 917.96.350, 836.07.002]
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Parallels between T cell kinetics in mice and men have fueled the idea that a young mouse is a good model system for a young human, and an old mouse, for an elderly human. By combining in vivo kinetic labeling using deuterated water, thymectomy experiments, analysis of T cell receptor excision circles and CD31 expression, and mathematical modeling, we have quantified the contribution of thymus output and peripheral naive T cell division to the maintenance of T cells in mice and men. Aging affected naive T cell maintenance fundamentally differently in mice and men. Whereas the naive T cell pool in mice was almost exclusively sustained by thymus output throughout their lifetime, the maintenance of the adult human naive T cell pool occurred almost exclusively through peripheral T cell division. These findings put constraints on the extrapolation of insights into T cell dynamics from mouse to man and vice versa.
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