Journal
IMMUNITY
Volume 36, Issue 6, Pages 1017-1030Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2012.03.024
Keywords
-
Categories
Funding
- NIAMS
- JSPS at NIH
- Istituto Pasteur-Fondazione Cenci-Bolognetti
- NIH [R01 AI 42334, R01 AI 40614, R37 AI 38310]
- NIAID
Ask authors/readers for more resources
Interleukin-27 (IL-27) is a key immunosuppressive cytokine that counters T helper 17 (Th17) cell-mediated pathology. To identify mechanisms by which IL-27 might exert its immunosuppressive effect, we analyzed genes in T cells rapidly induced by IL-27. We found that IL-27 priming of naive T cells upregulated expression of programmed death ligand 1 (PD-L1) in a signal transducer and activator of transcription 1 (STAT1)-dependent manner. When cocultured with naive CD4(+) T cells, IL-27-primed T cells inhibited the differentiation of Th17 cells in trans through a PD-1-PD-L1 interaction. In vivo, coadministration of naive TCR transgenic T cells (2D2 T cells) with IL-27-primed T cells expressing PD-L1 inhibited the development of Th17 cells and protected from severe autoimmune encephalomyelitis. Thus, these data identify a suppressive activity of IL-27, by which CD4(+) T cells can restrict differentiation of Th17 cells in trans.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available