Journal
IMMUNITY
Volume 37, Issue 3, Pages 389-398Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2012.08.011
Keywords
-
Categories
Funding
- National Institutes of Health (NIH) [AI081884, AI054359, AI062428, AI064705]
- NIH/NIAID [U54AI057160]
Ask authors/readers for more resources
In contrast to the extraordinary body of knowledge gained over the past three decades on the virology, pathogenesis, and immunology of HIV-1 infection, innate sensors that detect HIV-1 had remained elusive until recently. By virtue of integration, retroviridae makes up a substantial portion of our genome. Thus, immune strategies that deal with endogenous retroviruses are, by necessity, those of self-preservation and not of virus elimination. Some of the principles of such strategies may also apply for defense against exogenous retroviruses including HIV-1. Here, I highlight several sensors that have recently been revealed to be capable of recognizing distinct features of HIV-1 infection, while taking into account the host-retrovirus relationship that converges on avoiding pathogenic inflammatory consequences.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available