Journal
IMMUNITY
Volume 32, Issue 5, Pages 593-604Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2010.05.007
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Funding
- British Heart Foundation
- MRC [G0600727] Funding Source: UKRI
- Medical Research Council [G0600727] Funding Source: researchfish
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The concept of an alternative pathway of macrophage activation has stimulated interest in its definition, mechanism, and functional significance in homeostasis and disease. We assess recent research in this field, argue for a restricted definition, and explore pathways by which the T helper 2 (Th2) cell cytokines interleukin-4 (IL-4) and IL-13 mediate their effects on macrophage cell biology, their biosynthesis, and responses to a normal and pathological microenvironment. The stage is now set to gain deeper insights into the role of alternatively activated macrophages in immunobiology.
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