Vaccination Strategies to Promote Mucosal Antibody Responses

There are great interest and demand for the development of vaccines to prevent and treat diverse microbial infections Mucosal vaccines elicit immune protection by stimulating the production of antibodies at mucosal surfaces and systemic districts Being positioned in close proximity to a large community of commensal microbes, the mucosal immune system deploys a heterogeneous population of cells and a complex regulatory network to maintain the balance between surveillance and tolerance A successful mucosa, vaccine relies on leveraging the functions of these immune cells and regulatory components We review the important cellular interactions and molecular pathways underlying the induction and regulation of mucosal antibody responses and discuss their implications on mucosal vaccination