Journal
IMMUNITY
Volume 32, Issue 1, Pages 29-40Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2009.10.009
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Funding
- MEXT
- Specially Promoted Research
- Astellas Foundation
- Mitsubishi Foundation
- Grants-in-Aid for Scientific Research [19059010, 22590437] Funding Source: KAKEN
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How self-peptides displayed in the thymus contribute to the development of immunocompetent and self-protective T cells is largely unknown. In contrast, the role of thymic self-peptides in eliminating self-reactive T cells and thereby preventing autoimmunity is well established. A type of proteasome, termed thymoproteasome, is specifically expressed by thymic cortical epithelial cells (cTECs) and is required for the generation of optimal cellularity of CD8(+) T cells. Here, we show that cTECs displayed thymoproteasome-specific peptide-MHC class I complexes essential for the positive selection of major and diverse repertoire of MHC class I-restricted T cells. CD8(+) T cells generated in the absence of thymoproteasomes displayed a markedly altered T cell receptor repertoire that was defective in both allogeneic and antiviral responses. These results demonstrate that thymoproteasome-dependent self-peptide production is required for the development of an immunocompetent repertoire of CD8(+) T cells.
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