NF-κB-ISGF3 Transcription Factor Cooperation: Coincidence Detector or Memory Chip?

Induction of gene expression involves deployment of transcription factors. In this issue of Immunity, Farlik et al. (2010) provide a view in which cooperation between transcription factors NF-kappa B and ISGF3 divides the task of transcription by recruiting and activating distinct components of the transcriptional machinery.