Journal
IMMUNITY
Volume 29, Issue 6, Pages 1009-1021Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2008.10.010
Keywords
-
Categories
Funding
- Intramural NIH HHS [Z01 AI000855-09] Funding Source: Medline
Ask authors/readers for more resources
Virus-specific CD8(+) T cells probably mediate control over HIV replication in rare individuals, termed long-term nonprogressors; (LTNPs) or elite controllers. Despite extensive investigation, the mechanisms responsible for this control remain incompletely understood. We observed that HIV-specific CD8(+) T cells of LTNPs persisted at higher frequencies than those of treated progressors with equally low amounts of HIV. Measured on a per-cell basis, HIV-specific CDB+ T cells of LTNPs efficiently eliminated primary autologous HIV-infected CD4(+) T cells. This function required lytic granule loading of effectors and delivery of granzyme B to target cells. Defective cytotoxicity of progressor effectors could be restored after treatment with phorbol ester and calcium ionophore. These results establish an effector function and mechanism that clearly segregate with immunologic control of HIV. They also demonstrate that lytic granule contents of memory cells are a critical determinant of cytotoxicity that must be induced for maximal per-cell killing capacity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available