Journal
IMMUNITY
Volume 29, Issue 3, Pages 352-361Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2008.09.002
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Funding
- National Health and Medical Research Council of Australia
- The University of Melbourne
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One of the remaining enigmas of the dendritic cell (DC) network is the potential contribution of plasmacytoid DCs (pDCs) to antigen presentation. Although the antigen-presentation capacity of conventional DCs (cDCs) is clearly defined, pDCs are generally attributed as having little, if any, antigen-presentation function. Instead, pDCs are regarded as immunomodulating cells, capable of directing the immune response through their secretion of large amounts of type I interferons. In this review, we examine the evidence for a potential role of pDC in antigen capture, processing, and presentation to T cells at sites of infection and in the lymph nodes.
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