Journal
IMMUNITY
Volume 28, Issue 6, Pages 735-739Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2008.05.005
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Mitochondrial antiviral immunity involves the detection of viral RNA by intracellular pattern-recognition receptors (PRRs) belonging to the RIG-I-like helicase family. The convergence of these and other signaling molecules to the outer mitochondrial membrane results in the rapid induction of antiviral cytokines including type-1 interferon. Here, we discuss recent studies describing new molecules implicated in the regulation of this antiviral response.
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