Journal
IMMUNITY
Volume 29, Issue 5, Pages 675-678Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2008.10.004
Keywords
-
Categories
Funding
- MRC
- Wellcome Trust
- MRC [G0400808] Funding Source: UKRI
- Medical Research Council [G0400808] Funding Source: researchfish
Ask authors/readers for more resources
Paired receptors are families of membrane proteins containing similar extracellular regions but differing in their potential for signaling with one type able to give inhibitory signals and the other activating. Inhibitory receptors could be good targets for pathogens to restrict immune responses against them. Here we suggest that activating members may have evolved to counterbalance pathogens utilizing the inhibitory pathway. Thus, if a pathogen utilizes any part of the inhibitory receptor to downregulate responses against itself, it may, because of similarities in structure, also bind the activating receptor and give an opposing signal. We evaluate recent structural data on SIRP alpha (signal regulatory protein) and LILRB1 (leukocyte immunoglobulin-like receptor subfamily B member 1) showing evidence of pathogen pressure in nonligand-binding regions of these receptors together with data on pathogen binding to PIRs (paired Ig-like receptors) to provide support for this theory.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available