Journal
ILAR JOURNAL
Volume 55, Issue 2, Pages 333-346Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ilar/ilu019
Keywords
anxiety; cognitive bias; human intruder test; macaque; marmoset; startle test
Categories
Funding
- Oregon National Primate Research Center [8P51OD011092-53]
- Wisconsin National Primate Research Center [P51OD011106]
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Anxiety can be broadly described as a psychological state in which normally innocuous environmental stimuli trigger negative emotional expectations. Human anxiety disorders are multidimensional and may be organic or acquired, situational or pervasive. The broad ranging nature of the anxiety phenotype speaks to the need for models that identify its various components and root causes to develop effective clinical treatments. The cross-species comparative approach to modeling anxiety disorders in animals aims to understand mechanisms that both contribute to and modulate anxiety. Nonhuman primate models provide an important bridge from nonprimate model systems because of the complexity of nonhuman primates' biobehavioral capacities and their commonalities with human emotion. The broad goal of this review is to provide an overview of various procedures available to study anxiety in the nonhuman primate, with a focus on the behavioral aspects of anxiety. Commonly used methods covered in this review include assessing animals in their home environment or in response to an ethologically relevant threat, associative conditioning and startle response tests, and cognitive bias tests. We also discuss how these procedures can help veterinarians and researchers care for captive nonhuman primates.
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