Journal
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
Volume 9, Issue 5, Pages 1535-1538Publisher
IEEE COMPUTER SOC
DOI: 10.1109/TCBB.2012.89
Keywords
Antibacterial; antifungal; antimicrobial; antiviral; prediction algorithm; random forests; SVM
Categories
Funding
- Department of Science and Technology, Government of India [SR/S3/CE/52/2007]
- NIRRH [NIRRH/A/15/11]
- Indian Council of Medical Research [63/128/2001-BMS]
- CSIR
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Antimicrobial peptides (AMPs) are gaining popularity as anti-infective agents. Information on sequence features that contribute to target specificity of AMPs will aid in accelerating drug discovery programs involving them. In this study, an algorithm called ClassAMP using Random Forests (RFs) and Support Vector Machines (SVMs) has been developed to predict the propensity of a protein sequence to have antibacterial, antifungal, or antiviral activity. ClassAMP is available at http://www.bicnirrh.res.in/classamp/.
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