Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 48, Issue -, Pages 651-662Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2014.12.068
Keywords
Growth factors; Wound healing; Chronic wounds; Wound dressings; Stem cells; siRNA; Sensors
Categories
Funding
- National Institute of Health (NIH) [R01DE023356]
- National Science Foundation (NSF) [1312465]
- Div Of Industrial Innovation & Partnersh
- Directorate For Engineering [1312465] Funding Source: National Science Foundation
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In this review, we describe current and future potential wound healing treatments for acute and chronic wounds. The current wound healing approaches are based on autografts, allografts, and cultured epithelial autografts, and wound dressings based on biocompatible and biodegradable polymers. The Food and Drug Administration approved wound healing dressings based on several polymers including collagen, silicon, chitosan, and hyaluronic acid. The new potential therapeutic intervention for wound healing includes sustained delivery of growth factors, and siRNA delivery, targeting microRNA, and stem cell therapy. In addition, environment sensors can also potentially utilize to monitor and manage microenvironment at wound site. Sensors use optical, odor, pH, and hydration sensors to detect such characteristics as uric acid level, pH, protease level, and infection - all in the hopes of early detection of complications. (C) 2014 Elsevier B.V. All rights reserved.
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