Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 48, Issue -, Pages 235-242Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2014.12.003
Keywords
Warfarin; Magnetic nanoparticles; Square wave voltammetry; Carbon paste modified electrode
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Funding
- Razi University Research [57021]
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In the present work, a simple and sensitive electrochemical sensor based on magnetic Fe3O4 nanoparticles modified carbon paste electrode (CPE) was introduced for detection of low level with 0.21 mu M of warfarin. Under the optimum experimental conditions the oxidation peak current of warfarin was used for its monitoring for the first time. The analytical curve was linear for warfarin concentrations from 0.5 to 1000 mu M with a limit of detection of 021 mu M by square wave anodic stripping voltammetry (SWASV). The proposed sensor showed excellent stability and was used for the determination of warfarin in tablet, human serum and urine with satisfactory results. (C) 2014 Elsevier B.V. All rights reserved.
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