Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 46, Issue -, Pages 195-201Publisher
ELSEVIER
DOI: 10.1016/j.msec.2014.10.028
Keywords
Crosslinked hydrogel; Polyethyleneglycol dicarboxylate; Electron beam; Tensile strength; Elongation at break; Anti-adhesion barrier
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Funding
- National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [20110008342]
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The cross-linked poly(ethylene glycol) dicarboxylate (PEGDC)/poly(ethylene oxide) (PEO) and poly(ethylene glycol) dimethacrylate (PEGDMA)/(PEO) hydrogels were developed for possible biomedical applications such as an anti-adhesion barrier. Various contents of PEGDC/PEO film were irradiated using an electron beam with various beam intensities in order to obtain various degrees of crosslinked hydrogels. The optimum dose (300 kGy) and total crosslinker content of 10% were used to prepare crosslinked hydrogel films with three different compositions (10% PEGDC, 10% PEGDMA, 5% PEGDC-5% PEGDMA). Among them, 10% PEGDC hydrogel film exhibited the highest elongation at break (6933 +/- 6.87%) with high mechanical strength. 10% PEGDC hydrogel film showed the lowest hemolysis activity (6.03 +/- 0.01%) and the highest tissue adherence (75.67 +/- 1.15 cN). The result also indicated that the carboxyl groups in PEGDC affect the tissue adherence of hydrogel films via H-bonding interactions. In animal studies, 10% PEGDC anti-adhesion hydrogel film degraded within 3 weeks and demonstrated better anti-adhesive effect compared to Guardix-SG (R). (C) 2014 Elsevier B.V. All rights reserved.
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