Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 48, Issue -, Pages 487-498Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2014.12.036
Keywords
Fe3O4 magnetic nanoparticles; Chitosan; 5-Fluorouracil; Carboxymethyl-beta-cyclodextrin; Drug delivery
Categories
Funding
- Science and Technology Development Program of China [201303060]
- National Natural Science Foundation of China [50902059]
- Department of Education Fund of Shandong Province [J08LA02]
- Shandong Province Taishan Scholarship Foundation [BS2010CL004]
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In this study, a novel hydrogel, chitosan (CS) crosslinked carboxymethyl-beta-cyclodextrin (CM-beta-CD) polymer modified Fe3O4 magnetic nanoparticles was synthesized for delivering hydrophobic anticancer drug 5-fluorouracil (CS-CDpoly-MNPs). Carboxymethyl-beta-cyclodextrin being grafted on the Fe3O4 nanoparticles (CDpoly-MNPs) contributed to an enhancement of adsorption capacities because of the inclusion abilities of its hydrophobic cavity with insoluble anticancer drugs through host-guest interactions. Experimental results indicated that the amounts of crosslinking agent and bonding times played a crucial role in determining morphology features of the hybrid nanocarriers. The nanocarriers exhibited a high loading efficiency (44.7 +/- 1.8%) with a high saturation magnetization of 43.8 emu/g. UV-Vis spectroscopy results showed that anticancer drug 5-fluorouracil (5-Fu) could be successfully included into the cavities of the covalently linked CDpoly-MNPs. Moreover, the free carboxymethyl groups could enhance the bonding interactions between the covalently linked CDpoly-MNPs and anticancer drugs. In vitro release studies revealed that the release behaviors of CS-CDpoly-MNPs carriers were pH dependent and demonstrated a swelling and diffusion controlled release. A lower pH value led to swelling effect and electrostatic repulsion contributing to the protonation amine impact of NH3+, and thus resulted in a higher release rate of 5-Fu. The mechanism of 5-Fu encapsulated into the magnetic chitosan nanoparticles was tentatively proposed. (C) 2014 Elsevier B.V. All rights reserved.
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