Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 56, Issue -, Pages 125-131Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2015.06.007
Keywords
Bio-deep eutectic solvent; Cephalopod like architecture; DNA; Antibacterial; Bactericidal activity
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Funding
- CSIR, New Delhi [CSIR-YSP/2011-12]
- CSIR for NET
- CSIR under CSIR-YSP
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2.5% w/w DNA (Salmon testes) was solubilized in a bio-deep eutectic solvent [(bio-DES), obtained by the complexation of choline chloride and ethylene glycol at 1:2 molar ratio] containing 1% w/w of silver chloride (AgCl) to yield a AgCl decorated DNA based hybrid material. Concentration dependent formation of AgCl crystals in the DES was observed and upon interaction with DNA it gave formation of a cephalopod shaped hybrid material. DNA was found to Maintain its chemical and structural stability in the material. Further, AgCl microstructures were found to have orderly self assembled on the DNA helices indicating the electrostatic interaction between Ag+ and phosphate side chain of DNA as a driving force for the formation of the material with ordered microstructural distribution of AgCl. Furthermore, the functionalized material exhibited excellent antibacterial and bactericidal activity against both Gram negative and Gram positive pathogenic bacteria. (C) 2015 Elsevier B.V. All rights reserved.
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