Journal
MATERIALS LETTERS
Volume 148, Issue -, Pages 163-166Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2015.02.070
Keywords
Polyphosphate; Regenerative medicine; SaOS-2 cells; Morphogenetic activity; Tissue engineering
Funding
- ERC Advanced Investigator Grant [268476 BIOSILICA]
- European Commission [604036, 286059, 268476, 311848]
- International Human Frontier Science Program
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Polyphosphate [polyP] has been proven to elicit morphogenetic activity on bone cells. By applying mild reaction conditions, a Ca-polyP material that displays a hardness of approximate to 1.3 GPa has been fabricated. The Ca-polyP granules are prone to hydrolytic degradation during in vitro incubation of the cells, suggesting that this property is associated with the observed bioactivity. (C) 2015 Elsevier B.V. All rights reserved.
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