4.5 Article

The System Design, Engineering Architecture, and Preliminary Results of a Lower-Cost High-Sensitivity High-Resolution Positron Emission Mammography Camera

Journal

IEEE TRANSACTIONS ON NUCLEAR SCIENCE
Volume 57, Issue 1, Pages 104-110

Publisher

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TNS.2009.2031644

Keywords

Nuclear imaging; nuclear medical applications; PET instrumentation

Funding

  1. U.S. Army Breast Cancer Research
  2. [NIH-RO1-CA76246 PHS]
  3. [NIH-RO1-EB000217 PHS]
  4. [NIH-RO1-EB001038 PHS]
  5. [NIH-RO1-EB001481 PHS]

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A lower-cost high-sensitivity high-resolution positron emission mammography (PEM) camera is developed. It consists of two detector modules with the planar detector bank of 20 x 12 cm(2). Each bank has 60 low-cost PMT-Quadrant-Sharing (PQS) LYSO blocks arranged in a 10 x 6 array with two types of geometries. One is the symmetric 19.36 x 19.36 mm(2) block made of 1.5 x 1.5 10 mm(3) crystals in a 12 x 12 array. The other is the 19.36 x 26.05 mm(2) asymmetric block made of 1.5 x 1.9 x 10 mm(3) crystals in 12 x 13 array. One row (10) of the elongated blocks are used along one side of the bank to reclaim the half empty PMT photocathode in the regular PQS design to reduce the dead area at the edge of the module. The bank has a high overall crystal packing fraction of 88%, which results in a very high sensitivity. Mechanical design and electronics have been developed for low-cost, compactness, and stability purposes. Each module has four Anger-HYPER decoding electronics that can handle a count-rate of 3 Mcps for single events. A simple two-module coincidence board with a hardware delay window for random coincidences has been developed with an adjustable window of 6 to 15 ns. Some of the performance parameters have been studied by preliminary tests and Monte Carlo simulations, including the crystal decoding map and the 17% energy resolution of the detectors, the point source sensitivity of 11.5% with 50 mm bank-to-bank distance, the 1.2 mm-spatial resolutions, 42 kcps peak Noise Equivalent Count Rate at 7.0-mCi total activity in human body, and the resolution phantom images. Those results show that the design goal of building a lower-cost, high-sensitivity, high-resolution PEM detector is achieved.

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