Journal
MATERIALS LETTERS
Volume 160, Issue -, Pages 31-33Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2015.07.055
Keywords
Phase separation; Polymer solution; Morphology; Pore size gradient
Funding
- European Structural Funds - PON [PON01_01287]
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Foams with a pore size gradient are promising materials for tissue engineering applications where a complex architecture involving morphological variations in space must be mimicked, e.g. in bone tissue repair. In this paper, a technique to obtain a porous scaffold with a pore size gradient is presented. The preparation procedure is based on Thermally Induced Phase Separation (TIPS), by imposing a different thermal history on the two sides of a polymeric solution. In this way, a gradient in thermal history is produced, which will generate a pore size monotonously varying along scaffold thickness. By controlling some parameters easy to manipulate, such as demixing temperature and/or residence time in the miscibility gap region, the pore size range can be easily tuned. (C) 2015 Elsevier B.V. All rights reserved.
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