Journal
MATERIALS LETTERS
Volume 143, Issue -, Pages 302-304Publisher
ELSEVIER
DOI: 10.1016/j.matlet.2014.12.140
Keywords
Silk fibroin; Ionic liquid; Chemical modification; Sulfation; Biomaterials; Functional polymers
Funding
- National Natural Science Foundation of China [51103110, 51325306]
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Ionic liquid, 1-butyl-3-methylimidazolium chloride, was used as the solvent of silk fibroin (SF) polymer for its homogeneous chemical modification by chlorosulfonic acid in a non-aqueous system. The sulfation of SF in the ionic liquid possesses several obvious advantages, such as mild reaction condition, high modification degree, low degradation and requiring no dialysis process. The incorporation of sulfate groups was confirmed by infrared spectroscopy and its amount was measured by elemental analysis. H-1 NMR spectra revealed that the sulfation occurred mainly at tyrosine and serine residues. The coagulation time tests showed the anticoagulant activity of SF which was induced by the incorporated group. (C) 2015 Elsevier B.V. All rights reserved.
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