Journal
MALARIA: ADVANCES IN PATHOPHYSIOLOGY, BIOLOGY, AND DRUG DEVELOPMENT
Volume 1342, Issue -, Pages 62-67Publisher
BLACKWELL SCIENCE PUBL
DOI: 10.1111/nyas.12766
Keywords
malaria; drug resistance; artemisinin-based combination therapy; artemisinin resistance; molecular epidemiology; Africa
Categories
Funding
- NIAID NIH HHS [R01 AI101713] Funding Source: Medline
Ask authors/readers for more resources
Drug-resistant parasites repeatedly arise as a result of widespread use of antimalarial drugs and have contributed significantly to the failure to control and eradicate malaria throughout the world. In this review, we describe the spread of resistance to chloroquine and sulfadoxine-pyrimethamine, two old drugs that are no longer used owing to high rates of resistance, and examine the effect of the removal of drug pressure on the survival of resistant parasites. Artemisinin-resistant malaria is now emerging in Southeast Asia in a unique and unexpected pattern. We will review the most recent genomic and clinical data to help predict the behavior of resistance to new antimalarial medications and inform strategies to prevent the spread of drug-resistant malaria in Africa in the future.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available