Journal
DIET, SULFUR AMINO ACIDS, AND HEALTH SPAN
Volume 1363, Issue -, Pages 91-98Publisher
BLACKWELL SCIENCE PUBL
DOI: 10.1111/nyas.12956
Keywords
one-carbon metabolism; epigenetics; histone methylation; histone methyltransferase
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Funding
- NATIONAL CANCER INSTITUTE [R01CA193256, R21CA201963, R00CA168997] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007273] Funding Source: NIH RePORTER
- NCI NIH HHS [R01CA193256, R01 CA193256, R00 CA168997, R00CA168997, R21 CA201963] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007273, T32GM007273] Funding Source: Medline
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One-carbon metabolism is a metabolic network that integrates nutrient status from the environment to yield multiple biological functions. The folate and methionine cycles generate S-adenosylmethionine (SAM), which is the universal methyl donor for methylation reactions, including histone and DNA methylation. Histone methylation is a crucial part of the epigenetic code and plays diverse roles in the establishment of chromatin states that mediate the regulation of gene expression. The activities of histone methyltransferases (HMTs) are dependent on intracellular levels of SAM, which fluctuate based on cellular nutrient availability, providing a link between cell metabolism and histone methylation. Here we discuss the biochemical properties of HMTs, their role in gene regulation, and the connection to cellular metabolism. Our emphasis is on understanding the specificity of this intriguing link.
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