Journal
MATERIALS LETTERS
Volume 153, Issue -, Pages 143-147Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2015.04.013
Keywords
Bioactive glass; Serum proteins; In vitro bioactivity; Fluorapatite; Cell culture medium
Funding
- QMUL International Science and Excellence Award
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Five bioactive glass compositions in the SiO2-P2O5-CaO-Na2O-CaF2 system (0-32 mol% CaF2) and Bioglass (R) 45S5 were evaluated for their apatite forming ability in serum-free and serum-containing cell culture media for up to seven days. While F- ions in low concentrations were found to enhance apatite formation, higher fluoride content caused formation of fluorite and calcite. The presence of serum proteins delayed apatite precipitation for all compositions, while Bioglass (R) 45S5, despite considerably higher phosphate content (2.6 vs. <= 1.1 mol% P2O5) and high concentrations of Ca2+ and PO43- in solution, formed only amorphous calcium phosphate. (C) 2015 Elsevier B.V. All rights reserved.
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