Journal
IEEE TRANSACTIONS ON MEDICAL IMAGING
Volume 28, Issue 8, Pages 1190-1197Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TMI.2008.2011899
Keywords
High-frequency ultrasound; multichannel receiver electronics; photoacoustic imaging; transducer array
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Funding
- National Institute of Health [R01 EB000712, P41-EB2182]
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This paper discusses the design of a novel photoacoustic microscopy imaging system with promise for studying the structure of tissue microvasculature for applications in visualizing angiogenesis. A new 16 channel analog and digital high-frequency array based photoacoustic microscopy system (PAM) was developed using an Nd: YLF pumped tunable dye laser, a 30 MHz piezo composite linear array transducer, and a custom multichannel receiver electronics system. Using offline delay and sum beam-forming and beamsteering, phantom images were obtained from a 6 m carbon fiber in water at a depth of 8 mm. The measured -6 dB lateral and axial spatial resolution of the system was 100 +/- 5 mu m and 45 +/- 5 mu m, respectively. The dynamic focusing capability of the system was demonstrated by imaging a composite carbon fiber matrix through a 12.5 mm imaging depth. Next, 2-D in vivo images were formed of vessels around 100 mu m in diameter in the human hand. Three-dimensional in vivo images were also formed of micro-vessels 3 mm below the surface of the skin in two Sprague Dawley rats.
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