Journal
MITOCHONDRIAL RESEARCH IN TRANSLATIONAL MEDICINE
Volume 1350, Issue -, Pages 107-116Publisher
BLACKWELL SCIENCE PUBL
DOI: 10.1111/nyas.12885
Keywords
calcium signaling; mitochondrial calcium uptake; cell death; MICU1; mitochondrial permeability transition pore; ischemia/reperfusion injury
Funding
- Muscular Dystrophy U.K.
- Biotechnology and Biological Sciences Research Council (BBSRC)
- GSK through a CASE Ph.D. studentship
- MRC [MR/K000608/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [1330466, 1675658] Funding Source: researchfish
- Medical Research Council [MR/K000608/1] Funding Source: researchfish
Ask authors/readers for more resources
Calcium signaling is pivotal to a host of physiological pathways. A rise in calcium concentration almost invariably signals an increased cellular energy demand. Consistent with this, calcium signals mediate a number of pathways that together serve to balance energy supply and demand. In pathological states, calcium signals can precipitate mitochondrial injury and cell death, especially when coupled to energy depletion and oxidative or nitrosative stress. This review explores the mechanisms that couple cell signaling pathways to metabolic regulation or to cell death. The significance of these pathways is exemplified by pathological case studies, such as those showing loss of mitochondrial calcium uptake 1 in patients and ischemia/reperfusion injury.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available