Journal
IEEE TRANSACTIONS ON INFORMATION TECHNOLOGY IN BIOMEDICINE
Volume 16, Issue 6, Pages 1127-1134Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TITB.2011.2165076
Keywords
Classification; decision support system (DSS); gene expression; oral cancer; reoccurrence prediction
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Funding
- European Commission [FP7-ICT-2007-224483-ICT]
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Oral squamous cell carcinoma (OSCC) constitutes the predominant neoplasm of the head and neck region, featuring particularly aggressive nature, associated with quite unfavorable prognosis. In this paper, we formulate a decision support system that integrates a multitude of heterogeneous data (clinical, imaging, and genomic), thus, framing all manifestations of the disease. Our primary aim is to identify the factors that dictate OSCC progression and subsequently predict potential relapses (local or metastatic) of the disease. The discrimination potential of each source of data is initially explored separately, and afterward the individual predictions are combined to yield a consensus decision achieving complete discrimination between patients with and without a disease relapse.
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