Journal
MARINE DRUGS
Volume 13, Issue 8, Pages 4814-4914Publisher
MDPI
DOI: 10.3390/md13084814
Keywords
indoles; alkaloids; marine natural products; bisindoles; nitrogen heterocycles; carbolines; prenylated indoles; diketopiperazines
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Funding
- Rhineland Palatinate Natural Product Research Center
- Zeiss foundation
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Marine indole alkaloids comprise a large and steadily growing group of secondary metabolites. Their diverse biological activities make many compounds of this class attractive starting points for pharmaceutical development. Several marine-derived indoles were found to possess cytotoxic, antineoplastic, antibacterial and antimicrobial activities, in addition to the action on human enzymes and receptors. The newly isolated indole alkaloids of marine origin since the last comprehensive review in 2003 are reported, and biological aspects will be discussed.
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