Journal
MARINE DRUGS
Volume 13, Issue 1, Pages 202-221Publisher
MDPI
DOI: 10.3390/md13010202
Keywords
bioactivity; marine natural products; quantitative analysis; novel compounds
Categories
Funding
- Natural Science Foundation of China [81102370, 41176128]
- China's Marine Commonweal Research Project [201305017]
- National Science and Technique Major Project [2012ZX09102101-017]
- Key Science and Technique Research Project of Guangzhou [12B292060029]
- Special Financial Fund of Innovative Development of Marine Economic Demonstration Project [GD2012-D01-001]
- Guangdong Department of Science & Technology Translational Medicine Center Grant [2011A080300002]
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Every year, hundreds of new compounds are discovered from the metabolites of marine organisms. Finding new and useful compounds is one of the crucial drivers for this field of research. Here we describe the statistics of bioactive compounds discovered from marine organisms from 1985 to 2012. This work is based on our database, which contains information on more than 15,000 chemical substances including 4196 bioactive marine natural products. We performed a comprehensive statistical analysis to understand the characteristics of the novel bioactive compounds and detail temporal trends, chemical structures, species distribution, and research progress. We hope this meta-analysis will provide useful information for research into the bioactivity of marine natural products and drug development.
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