Journal
MARINE DRUGS
Volume 13, Issue 8, Pages 4617-4632Publisher
MDPI
DOI: 10.3390/md13084617
Keywords
marine fungi; lindgomycin; antibiotic; MRSA; marine natural products
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Funding
- National Science Foundation of China (NSFC) [81273386]
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An unusual polyketide with a new carbon skeleton, lindgomycin (1), and the recently described ascosetin (2) were extracted from mycelia and culture broth of different Lindgomycetaceae strains, which were isolated from a sponge of the Kiel Fjord in the Baltic Sea (Germany) and from the Antarctic. Their structures were established by spectroscopic means. In the new polyketide, two distinct domains, a bicyclic hydrocarbon and a tetramic acid, are connected by a bridging carbonyl. The tetramic acid substructure of compound 1 was proved to possess a unique 5-benzylpyrrolidine-2,4-dione unit. The combination of 5-benzylpyrrolidine-2,4-dione of compound 1 in its tetramic acid half and 3-methylbut-3-enoic acid pendant in its decalin half allow the assignment of a new carbon skeleton. The new compound 1 and ascosetin showed antibiotic activities with IC50 value of 5.1 (+/- 0.2) mu M and 3.2 (+/- 0.4) M, respectively, against methicillin-resistant Staphylococcus aureus.
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