Journal
MARINE DRUGS
Volume 13, Issue 2, Pages 1037-1050Publisher
MDPI
DOI: 10.3390/md13021037
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- National Museum of Marine Biology and Aquarium
- National Dong Hwa University
- Asia-Pacific Ocean Research Center, National Sun Yat-sen University
- Ministry of Science and Technology [NSC101-2320-B-291-001-MY3, MOST 103-2325-B-291-001]
- China Medical University under the Aim for Top University Plan of the Ministry of Education, Taiwan
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Two new briarane-type diterpenoids, briarenolides K (1) and L (2), were isolated from an octocoral identified as Briareum sp. The structures of new briaranes 1 and 2 were elucidated by spectroscopic methods. In the in vitro anti-inflammatory effects test, briaranes 1 and 2 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.
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