Journal
MARINE DRUGS
Volume 13, Issue 1, Pages 276-287Publisher
MDPI AG
DOI: 10.3390/md13010276
Keywords
mangrove plant; endophytic fungus; Pencillium brocae; secondary metabolites; antimicrobial activity
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Funding
- National Natural Science Foundation of China [31270403]
- Ministry of Science and Technology of China [2013AA092901, 2010CB833802]
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Five new sulfide diketopiperazine derivatives, namely, penicibrocazines A-E (1-5), along with a known congener (6), were isolated and identified from the culture extract of Penicillium brocae MA-231, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of these compounds were elucidated by detailed interpretation of NMR and mass spectroscopic data and the structures of compounds 1 and 3 were confirmed by single-crystal X-ray diffraction analysis. All these compounds were examined for cytotoxic and antimicrobial activities. Compounds 2-6 exhibited antimicrobial activity against some of the tested strains with MIC values ranging from 0.25 to 64 mu g/mL.
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