Journal
MARINE DRUGS
Volume 13, Issue 11, Pages 6884-6909Publisher
MDPI
DOI: 10.3390/md13116884
Keywords
TNF; TRAIL; Apoptosis; resistance; cancer; marine drugs; alkaloids; carotenoids; sesquiterpenes; macrolactones
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Funding
- program Investissements d'Avenir [ANR-11-LABX-0021-01-LipSTIC Labex]
- Conseil Regional de Bourgogne
- INCa (Institut National du Cancer) [PLBIO14-007]
- European Regional Development FEDER funds
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Marine biomass diversity is a tremendous source of potential anticancer compounds. Several natural marine products have been described to restore tumor cell sensitivity to TNF-related apoptosis inducing ligand (TRAIL)-induced cell death. TRAIL is involved during tumor immune surveillance. Its selectivity for cancer cells has attracted much attention in oncology. This review aims at discussing the main mechanisms by which TRAIL signaling is regulated and presenting how marine bioactive compounds have been found, so far, to overcome TRAIL resistance in tumor cells.
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