Journal
MARINE DRUGS
Volume 13, Issue 8, Pages 4721-4732Publisher
MDPI
DOI: 10.3390/md13084721
Keywords
porphyra-334; Nrf-2; NF-B; oxidative stress
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Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2012R1A6A1028677]
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In this study, we examined the protective effects of porphyra-334 against UVA-irradiated cellular damage and elucidated the underlying mechanisms. Porphyra-334 prevented UVA-induced cell death and exhibited scavenging activities against intracellular oxidative stress induced by UVA irradiation in skin fibroblasts. We found that porphyra-334 significantly reduced the secretion and expression of IL-6 and TNF-, reduced nuclear expression of Nuclear factor-B (NF-B), and sustained NF-E2-related factor 2 (Nrf2) activation. Further mechanism research revealed that porphyra-334 promoted the Nrf2 signaling pathway in UVA-irradiated skin fibroblasts. Our results show that the antioxidant effect of porphyra-334 is due to the direct scavenging of oxidative stress and its inhibitory effects on NF-B-dependent inflammatory genes, such as IL-6 and TNF-. Therefore, we hypothesize that boosting the Nrf2- NF-B-dependent response to counteract environmental stress is a promising strategy for the prevention of UVA-related damage.
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