Journal
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
Volume 59, Issue 5, Pages 1199-1204Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBME.2012.2183593
Keywords
Capacitive micromachined ultrasound transducer (CMUT) array; deep tissue imaging; optoacoustic; photoacoustic
Categories
Funding
- Canary Foundation
- National Cancer Institute (NCI) In Vivo Cellular and Molecular Imaging Center [P50 CA114747]
- NCI Center for Cancer Nanotechnology Excellence and Translation [U54CA151459]
- NIH [CA 99059, CA 134720]
- Sir Peter and Lady Michael Foundation
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In this paper, we demonstrate 3-D photoacoustic imaging (PAI) of light absorbing objects embedded as deep as 5 cm inside strong optically scattering phantoms using a miniaturized (4 mm x 4 mm x 500 mu m), 2-D capacitive micromachined ultrasonic transducer (CMUT) array of 16 x 16 elements with a center frequency of 5.5 MHz. Two-dimensional tomographic images and 3-D volumetric images of the objects placed at different depths are presented. In addition, we studied the sensitivity of CMUT-based PAI to the concentration of indocyanine green dye at 5 cm depth inside the phantom. Under optimized experimental conditions, the objects at 5 cm depth can be imaged with SNR of about 35 dB and a spatial resolution of approximately 500 mu m. Results demonstrate that CMUTs with integrated front-end amplifier circuits are an attractive choice for achieving relatively high depth sensitivity for PAI.
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