Journal
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
Volume 59, Issue 5, Pages 1219-1228Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBME.2011.2112359
Keywords
Human electromechanical model; monodomain; numerical methods; solid mechanics
Categories
Funding
- Medical Research Council [G0800980]
- Engineering and Physical Sciences Research Council [EP/F043929/1, EP/G007527/2]
- EPSRC [EP/F043929/1, EP/G007527/2] Funding Source: UKRI
- MRC [G0800980] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/G007527/2, EP/H019898/1, EP/F043929/1] Funding Source: researchfish
- Medical Research Council [G0800980] Funding Source: researchfish
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Strongly coupled cardiac electromechanical models can further our understanding of the relative importance of feedback mechanisms in the heart, but computational challenges currently remain a major obstacle, which limit their widespread use. To address this issue, we present a set of efficient computational methods including an efficient adaptive cell model integration scheme and a solution method for the monodomain equations that maintains high conduction velocity for time steps greater than 0.1 ms. We also present a novel method for increasing the efficiency of simulating electromechanical coupling, which shows a significant reduction in computational cost of the mechanical component on a personalized left ventricular geometry with an active contraction cell model reparametrized for human cells.
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