4.6 Article

Electrophysiological Imaging of Brain Activity and Connectivity-Challenges and Opportunities

Journal

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
Volume 58, Issue 7, Pages 1918-1931

Publisher

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBME.2011.2139210

Keywords

Electroencephalography (EEG); electrophysiological imaging; functional connectivity; functional magnetic resonance imaging (fMRI); magnetoencephalography (MEG); source imaging

Funding

  1. National Institute of Health [RO1 EB007920, RO1 EB006433, T32 EB008389]
  2. National Science Foundation [CBET-0933067]
  3. Div Of Chem, Bioeng, Env, & Transp Sys
  4. Directorate For Engineering [0933067] Funding Source: National Science Foundation

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Unlocking the dynamic inner workings of the brain continues to remain a grand challenge of the 21st century. To this end, functional neuroimaging modalities represent an outstanding approach to better understand the mechanisms of both normal and abnormal brain functions. The ability to image brain function with ever increasing spatial and temporal resolution has made a significant leap over the past several decades. Further delineation of functional networks could lead to improved understanding of brain function in both normal and diseased states. This paper reviews recent advancements and current challenges in dynamic functional neuroimaging techniques, including electrophysiological source imaging, multimodal neuroimaging integrating fMRI with EEG/MEG, and functional connectivity imaging.

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