Journal
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
Volume 57, Issue 10, Pages 2564-2567Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBME.2010.2053538
Keywords
Fluorescence imaging; optical imaging; tomography
Categories
Funding
- Project for the National Basic Research Program of China (973) [2006CB705700]
- Chinese Academy of Sciences [KGCX2-YW-907]
- Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT) [IRT0645]
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Fluorescence molecular tomography has become a promising technique for in vivo small animal imaging and has many potential applications. Due to the ill-posed and the ill-conditioned nature of the problem, Tikhonov regularization is generally adopted to stabilize the solution. However, the result is usually over-smoothed. In this letter, the third-order simplified spherical harmonics approximation to radiative transfer equation is utilized to model the photon propagation within biological tissues. Considering the sparsity of the fluorescent sources, we replace Tikhonov method with an iteratively reweighted scheme. By dynamically updating the weight matrix, L1-norm regularization can be approximated, which can promote the sparsity of the solution. Simulation study shows that this method can preserve the sparsity of the fluorescent sources within heterogeneous medium, even with very limited measurement data.
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