Journal
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
Volume 57, Issue 1, Pages 185-193Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBME.2009.2033465
Keywords
Biomedical applications of acoustic radiation; finite-element (FE) methods; focused ultrasound surgery (FUS); local harmonic motion (LHM) imaging; simulation
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Funding
- Academy of Finland
- Finnish Cultural Foundation
- North Savo Regional fund
- National Institutes of Health (NIH) [R33 CA102884]
- Ontario Research Fund
- NATIONAL CANCER INSTITUTE [R33CA102884] Funding Source: NIH RePORTER
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In this paper, a computational model for localized harmonic motion (LHM) imaging-based monitoring of high-intensity focused ultrasound surgery (FUS) is presented. The LHM technique is based on a focused, time-varying ultrasound radiation force excitation, which induces local oscillatory motions at the focal region. These vibrations are tracked, using pulse-echo imaging, and then, used to estimate the mechanical properties of the sonication region. LHM is feasible for FUS monitoring because changes in the material properties during the coagulation process affect the measured displacements. The presented model includes separate models to simulate acoustic sonication fields, sonication-induced temperature elevation and mechanical motion, and pulse-echo imaging of the induced motions. These 3-D simulationmodels are based on Rayleigh-Sommerfield integral, finite element, and spatial impulse response methods. Simulated-tissue temperature elevation and mechanical motion were compared with previously published in vivo measurements. Finally, the simulation model was used to simulate coagulation and LHM monitoring, as would occur with multiple, neighbouring sonication locations covering a large tumor.
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